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Chapter 35.Antidepressants

Edited by:
    https://doi.org/10.1176/appi.books.9781615374809.md35

    Sections

    Evaluating Antidepressant Studies | Outcome Assessments | Safety and Tolerability | Selective Serotonin Reuptake Inhibitors | Atypical Antidepressants | Tricyclic Antidepressants | Monoamine Oxidase Inhibitors | Alternative Antidepressant Treatments | References

    Excerpt

    Antidepressants are widely used in children and adolescents for a variety of disorders, with significant increases over the past 20 years. Primarily, antidepressants have been used for the same disorders as in adults (depression, anxiety), with additional potential use for ADHD, repetitive behaviors (e.g., autism spectrum disorders), and reactive aggression. Newer antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), have shown efficacy and safety in children and adolescents, with the greatest effect seen in obsessive-compulsive disorder (OCD) and anxiety disorders, followed by major depressive disorder (MDD). Limited data are available on pharmacokinetics and dosing in this age group, but medication dose and frequency may require adjustment (see also Chapter 33, “Principles of Psychopharmacology”).

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