Chapter 21.Neurocognitive Disorders With Lewy Bodies
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Excerpt
The Lewy body disorders are a group of neurodegenerative disorders that share the common pathology of fibrillar aggregates of α-synuclein protein in selective populations of neurons and glia. The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5; American Psychiatric Association 2013) presents current criteria for major or mild neurocognitive disorder with Lewy bodies and their applications in clinical practice. In this chapter, these conditions will be collectively referred to as dementia with Lewy bodies (DLB) when the cognitive-behavioral symptoms are the initial presentation and as Parkinson’s disease (PD) or Parkinson’s disease with dementia (PDD) if the movement disorder is the initial presentation and substantially precedes cognitive-behavioral symptoms.
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