Appendix A. Clinical Questions
The following key questions formed the basis of the Agency for Healthcare Research and Quality review:
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1a. What are the comparative benefits and harms of pharmacological treatments for adults with schizophrenia?
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1b. How do the benefits and harms of pharmacological treatments for adults with schizophrenia vary by patient characteristics?
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2a. What are the benefits and harms of psychosocial and other nonpharmacological treatments for adults with schizophrenia?
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2b. How do the benefits and harms of psychosocial and other nonpharmacological treatments for adults with schizophrenia vary by patient characteristics (e.g., age, sex, race, ethnicity, socioeconomic status, time since illness onset, prior treatment history, co-occurring psychiatric disorders, pregnancy)?
The following key questions formed the basis of searches related to neurological side effects of antipsychotic medications:
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1. What are the comparative benefits and harms of pharmacological treatments for acute dystonia associated with antipsychotic therapy?
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2. What are the comparative benefits and harms of pharmacological treatments for parkinsonism associated with antipsychotic therapy?
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3. What are the comparative benefits and harms of pharmacological treatments for akathisia associated with antipsychotic therapy?
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4. What are the comparative benefits and harms of pharmacological treatments for tardive syndromes associated with antipsychotic therapy?
