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The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia

Third Edition

Guideline Writing Group

APA wishes to acknowledge the contributions of APA staff and former staff (Jennifer Medicus, Seung-Hee Hong, Samantha Shugarman, Michelle Dirst, Kristin Kroeger Ptakowski). APA also wishes to acknowledge the contribution of Amanda S. Eloma, Pharm.D., BCPP, in reviewing information related to medications in the guideline and associated tables. In addition, APA and the Guideline Writing Group especially thank Laura J. Fochtmann, M.D., M.B.I.; Seung-Hee Hong; and Jennifer Medicus for their outstanding work and effort in developing this guideline. APA also thanks the APA Committee on Practice Guidelines (Daniel J. Anzia, M.D., Chair), liaisons from the APA Assembly for their input and assistance, and APA Councils and others for providing feedback during the comment period.

  1. George A. Keepers , M.D., Chair
  2. Laura J. Fochtmann , M.D., M.B.I., Vice-Chair; Methodologist
  3. Joan M. Anzia , M.D.
  4. Sheldon Benjamin , M.D.
  5. Jeffrey M. Lyness , M.D.
  6. Ramin Mojtabai , M.D.
  7. Mark Servis , M.D.
  8. Art Walaszek, M.D.
  9. Peter Buckley , M.D.
  10. Mark F. Lenzenweger , Ph.D.
  11. Alexander S. Young , M.D., M.S.H.S.
  12. Amanda Degenhardt , M.D.

Systematic Review Group

  1. Laura J. Fochtmann , M.D., M.B.I., Methodologist
  2. Seung-Hee Hong

Committee on Practice Guidelines

  1. Daniel J. Anzia , M.D., Chair
  2. R. Scott Benson , M.D.
  3. Thomas J. Craig , M.D.
  4. Catherine Crone , M.D.
  5. Annette L. Hanson , M.D.
  6. John M. Oldham , M.D.
  7. Carlos N. Pato , M.D., Ph.D.
  8. Michael J. Vergare , M.D.
  9. Joel Yager , M.D., Consultant
  10. Laura J. Fochtmann , M.D., M.B.I., Consultant

APA Assembly Liaisons

  1. Daniel Dahl , M.D.
  2. Bhasker Dave , M.D.
  3. Evan Eyler , M.D.
  4. Annette L. Hanson , M.D.
  5. Jason W. Hunziker , M.D.
  6. Marvin Koss , M.D.
  7. Robert M. McCarron , D.O.
  8. John P. D. Shemo , M.D.

The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards. As medical research and practice continue to advance, however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family.

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Copyright © 2021 American Psychiatric Association

ALL RIGHTS RESERVED

Third Edition

Manufactured in the United States of America on acid-free paper 24 23 22 21 20  5 4 3 2 1

American Psychiatric Association 800 Maine Avenue SW Suite 900 Washington, DC 20024-2812 www.appi.org

Library of Congress Cataloging-in-Publication Data Names: American Psychiatric Association, author, issuing body. Title: The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia / Guideline Writing Group, Systematic Review Group, Committee on Practice Guidelines. Other titles: Treatment of patients with schizophrenia Description: Third edition. | Washington, DC : American Psychiatric Association, [2021] | Preceded by: Practice guideline for the treatment of patients with schizophrenia. 2nd ed. c2004. | Includes bibliographical references. Identifiers: LCCN 2020016573 (print) | LCCN 2020016574 (ebook) | ISBN 9780890424698 (paperback ; alk. paper) | ISBN 9780890424742 (ebook) Subjects: MESH: Schizophrenia—therapy | Practice Guideline Classification: LCC RC514 (print) | LCC RC514 (ebook) | NLM WM 203 | DDC 616.89/8—dc23 LC record available at https://lccn.loc.gov/2020016573 LC ebook record available at https://lccn.loc.gov/2020016574

British Library Cataloguing in Publication Data A CIP record is available from the British Library.