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APA Practice Guidelines > Practice Guideline for the Treatment of Patients With Bipolar Disorder Second Edition > PART B: Background Information and Review of Available Evidence > IV. Disease Definition, Natural History and Course, and Epidemiology > A. Definition of Bipolar Disorder >

Table 5. Diagnostic Criteria for a Mixed Episode
Table 5. Diagnostic Criteria for a Mixed Episode
A. The criteria are met both for a manic episode and for a major depressive episode (except for duration) nearly every day during at least a 1-week period.
B. The mood disturbance 1) is sufficiently severe to cause marked impairment in occupational functioning, usual social activities, or relationships with others, 2) necessitates hospitalization to prevent harm to self or others, or 3) has psychotic features.
C. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or a general medical condition (e.g., hyperthyroidism).

Source. Adapted from DSM-IV-TR; mixed-like episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, ECT, light therapy) should not count toward a diagnosis of bipolar I disorder.


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